Difference between Serum and Plasma 4.47/5 (30)

Total Visits: 8,915
Please follow and like us:

Difference between Serum and Plasma

Difference between Serum and Plasma









1.DefinitionSerum is the liquid part of the blood after the coagulation.Plasma is a clear and yellowish fluid part of the blood.
2.CompositionSerum is the water fluid from blood without the clotting factors.Plasma is the blood fluid that contains blood clotting agents.
3.VolumeVolume of serum is less in comparison to plasma.Plasma is a clear yellow liquid which is 55% of total volume of blood.
4.IsolationSerum is acquired from the process of spinning after clotting.Plasma is acquired from the process of spinning before clotting.
5.Isolation ProcedureSerum is more difficult and time consuming to separate.Plasma is easier and less time consuming to separate as compared with serum.
6.Use of AnticoagulantsSerum does not need anticoagulants for separation.Anticoagulants are necessary to separate plasma.
7.CompositionSerum contains proteins, electrolytes, antibodies, antigens and hormones.Plasma is considered as the medium of blood in which RBCs (Red Blood Cells), WBC (White Blood Cells) and other components of blood are suspended.
8.Composition (Antibodies)Serum contain antibodies and cross react with recipient antigen.Plasma does not contain antibodies and not react with recipient antigen.
9.CompositionSerum contains proteins like albumin and globulins.Plasma contains the clotting factors and water.
11.Composition (Water)Serum contains 90% water.Plasma contains 92-95% water.
12.StorageSerum can be stored at 2-6 degrees centigrade for several days.Frozen plasma can be stored for up to a year.
13.DensitySerum has a density of approximately 1.024 g/ml.Plasma has a density of approximately 1025 kg/m3, or 1.025 g/ml.
14.ArrangementCells are usually attached together by clot formation.Cells are not attached together and suspended in plasma.
15.UsesSerum is the most preferred part of blood used in checking blood groups.Plasma is delivered to the patients who lack blood cells.
16.UsesSerum is an important source of electrolytes and animal sera are used as anti-venom, anti-toxins, and vaccinations.Plasma contains proteins that help in the transportation of material such as glucose and other dissolved nutrients through the blood.
17.UsesSerum is used for various diagnostic tests used for determining the levels of hCG, cholesterol, proteins, sugar, etc., in the blood.Plasma aids in the maintenance of blood pressure and in the regulation of body temperature


  1. http://medimoon.com/2012/07/difference-between-plasma-and-serum/
  2. https://www.reference.com/science/difference-between-plasma-serum-58673501a3b3e1af
  3. https://www.quora.com/What-is-difference-between-plasma-and-serum
  4. http://www.microbiologynotes.com/differences-between-serum-and-plasma/
  5. http://www.differencebetween.net/science/health/difference-between-plasma-and-serum/
  6. http://www.differencebetween.info/difference-between-plasma-and-serum
  7. http://www.protocol-online.org/biology-forums/posts/4959.html
  8. http://www.slideshare.net/nahomephrem/nahom-ppt
  9. http://health.onehowto.com/article/how-you-can-tell-the-difference-between-serum-and-plasma-1847.html
  10. http://gaduiblog.com/2009/05/01/blood-tests-the-differences-between-whole-blood-serum-and-plasma-2/
  11. http://www.differencebetween.com/difference-between-plasma-and-vs-serum/
  12. http://www.buzzle.com/articles/serum-vs-plasma.html
  13. http://www.actforlibraries.org/blood-specimens-the-differences-between-serum-and-plasma/
  14. http://www.prognosisquestions.com/question/whats-the-difference-between-serum-and-plasma-also-would-be-/Um4DLIL3LAJbAAC4
  15. https://www.researchgate.net/publication/7633729_Differences_between_serum_and_plasma_for_intact_parathyroid_hormone_measurement_in_patients_with_chronic_renal_failure_in_routine_clinical_practice
  16. http://www.gembio.com/post/what-difference-between-clot-and-plasma-derived-human-serum
  17. http://www.diffen.com/difference/Blood_vs_Plasma
  18. http://www.diffen.com/difference/Plasma_vs_Serum
  19. http://www.medical-labs.net/difference-between-plasma-and-serum-1531/
  20. https://astartebio.com/resources/featured-products/differences-between-serum-and-plasma

Difference between Serum and Plasma

Please rate this note

0 1 2 3 4 5

Share This:


The Author

Sagar Aryal

Sagar Aryal

I am Sagar Aryal, a passionate Microbiologist and the Scientific Blogger. I did my Master's Degree in Medical Microbiology and currently working as a Teaching Assistant at St. Xavier's College, Kathmandu, Nepal. I am particularly interested in research related to Medical Microbiology and Virology. Find me on Facebook, Twitter or Linkedin !!!

Leave a Reply

Your email address will not be published. Required fields are marked *

Microbiology Notes © 2014-2016            Site Created: 17th October, 2014            Copyright            Privacy Policy            Terms of Services            Contact Us