Difference between Serum and Plasma 4.58/5 (43)

Difference between Serum and Plasma

Difference between Serum and Plasma









1. Definition Serum is the liquid part of the blood after the coagulation. Plasma is a clear and yellowish fluid part of the blood.
2. Composition Serum is the water fluid from blood without the clotting factors. Plasma is the blood fluid that contains blood clotting agents.
3. Volume Volume of serum is less in comparison to plasma. Plasma is a clear yellow liquid which is 55% of total volume of blood.
4. Isolation Serum is acquired from the process of spinning after clotting. Plasma is acquired from the process of spinning before clotting.
5. Isolation Procedure Serum is more difficult and time consuming to separate. Plasma is easier and less time consuming to separate as compared with serum.
6. Use of Anticoagulants Serum does not need anticoagulants for separation. Anticoagulants are necessary to separate plasma.
7. Composition Serum contains proteins, electrolytes, antibodies, antigens and hormones. Plasma is considered as the medium of blood in which RBCs (Red Blood Cells), WBC (White Blood Cells) and other components of blood are suspended.
8. Composition (Antibodies) Serum contain antibodies and cross react with recipient antigen. Plasma does not contain antibodies and not react with recipient antigen.
9. Composition Serum contains proteins like albumin and globulins. Plasma contains the clotting factors and water.
10. Fibrinogen Absent Present
11. Composition (Water) Serum contains 90% water. Plasma contains 92-95% water.
12. Storage Serum can be stored at 2-6 degrees centigrade for several days. Frozen plasma can be stored for up to a year.
13. Density Serum has a density of approximately 1.024 g/ml. Plasma has a density of approximately 1025 kg/m3, or 1.025 g/ml.
14. Arrangement Cells are usually attached together by clot formation. Cells are not attached together and suspended in plasma.
15. Uses Serum is the most preferred part of blood used in checking blood groups. Plasma is delivered to the patients who lack blood cells.
16. Uses Serum is an important source of electrolytes and animal sera are used as anti-venom, anti-toxins, and vaccinations. Plasma contains proteins that help in the transportation of material such as glucose and other dissolved nutrients through the blood.
17. Uses Serum is used for various diagnostic tests used for determining the levels of hCG, cholesterol, proteins, sugar, etc., in the blood. Plasma aids in the maintenance of blood pressure and in the regulation of body temperature


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Difference between Serum and Plasma

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Sagar Aryal

I am Sagar Aryal, a passionate Microbiologist and the Scientific Blogger. I did my Master's Degree in Medical Microbiology and currently working as a Lecturer at Department of Microbiology, St. Xavier's College, Kathmandu, Nepal. I am particularly interested in research related to Medical Microbiology and Virology. Find me on Facebook, Twitter or Linkedin !!!


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